The Multifunctional Effects ofNiacinamide, Sodium Hyaluronate,and Hydrolyzed Collagen

Authors

DOI:

https://doi.org/10.5281/zenodo.21358943

Keywords:

Niacinamide, Sodium Hyaluronate

Abstract

Skin aging is characterized by moisture loss, a decrease in collagen, and a slowing of cellular renewal. During this process, structural and functional changes occur in the epidermis, dermis, and hypodermis layers. In this study, a multifunctional active complex containing hyaluronic acid, niacinamide, and hydrolyzed collagen was developed and incorporated into a facial serum at a 5% concentration. The formulation's efficacy was evaluated over a 4-week period on 20 female volunteers aged 25–39. Following the application of the serum twice daily, an increase in skin hydration and smoothness, as well as a reduction in dryness and the appearance of fine lines, was observed. The findings indicate that the developed active complex provides skin brightening and is effective in reducing signs of aging.

References

V. Nobile, D. Buonocore, A. Michelotti, and F. Marzatico, "Anti-aging and filling efficacy of six types hyaluronic acid based dermo-cosmetic treatment: Double blind, randomized clinical trial of efficacy and safety," J. Cosmet. Dermatol., vol. 13, no. 4, pp. 277–287, 2014, doi: 10.1111/jocd.12120.

H. Al-Atif, "Collagen supplements for aging and wrinkles: A paradigm shift in the field of dermatology and cosmetics," Dermatol. Pract. Concept., vol. 12, no. 1, art. e2022018, 2022, doi: 10.5826/dpc.1201a18.

E. Arca, M. Cayirli, E. Koc, and Z. Kurumlu, "Evaluation of efficacy and safety of niacinamide gel in the treatment of mild to moderate acne," Gulhane Med. J., vol. 55, no. 3, p. 167, 2013, doi: 10.5455/gulhane.22956.

Published

2026-06-30

How to Cite

The Multifunctional Effects ofNiacinamide, Sodium Hyaluronate,and Hydrolyzed Collagen. (2026). Aintelia Science Notes, 5(1), 67-70. https://doi.org/10.5281/zenodo.21358943